High prevalence and early onset of cardiac autonomic neuropathy among South Indian type 2 diabetic patients with nephropathy.

Full Abstract

OBJECTIVE: This study was conducted to assess the adverse effects of diabetic nephropathy on cardiovascular autonomic neuropathy (CAN) in South Indian Type 2 diabetic patients. METHODS: Comparison was made between Type 2 diabetic patients with nephropathy (group 1, n=25), Type 2 diabetic patients without nephropathy (group 2, n=25) and non-diabetic, non-hypertensive control subjects (n=20). All had a detailed clinical and biochemical work-up and cardiac assessment by ECG. Cardiac dysautonomia was assessed by a battery of five non-invasive autonomic function tests (ANF) as recommended by Ewing and Clarke [D.J. Ewing, B.F. Clarke, Diagnosis and Management of autonomic neuropathy. Br. Med. J. 285 (1982) 916-918]. RESULTS: Group 1 patients showed a higher percentage of abnormal CAN function and a more severe form of CAN compared with patients in group 2. Group 1 patients showed early development of the abnormalities. They also had a higher prevalence of peripheral neuropathy compared with the patients without nephropathy. CONCLUSIONS: The present study showed that the presence of nephropathy was associated with the risk of cardiac autonomic neuropathy in Type 2 diabetic patients and it probably had an earlier onset also in them.

Author information

Author/s: Viswanathan, V (V); Prasad, D (D); Chamukuttan, S (S); Ramachandran, A (A);

Affiliation: Diabetes Research Centre, No. 4 Main Road, Royapuram, Madras, India. dr_vijay(-atsign-)vsnl.com

Journal and publication information

Publication Type: Journal Article

Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract), published in IRELAND. (Language: eng)

Reference: 2000-Jun; vol 48 (issue 3) : pp 211-6

Dates: Created 2000/07/19; Completed 2000/07/19; Revised 2004/11/17;

PMID: 10802160, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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