Research article summary (published 30 Mar 2000):

Adipose replacement and wall motion abnormalities in right ventricle arrhythmias: evaluation by MR imaging. Retrospective evaluation on 124 patients.

Full Abstract

We reevaluated the magnetic resonance (MR) examinations of 38 healthy volunteers (control group, CG) and of 124 patients with RV arrhythmia with left bundle branch block (LBBB) morphology: 45 with episodes of RV sustained tachycardia and of polymorphic RV premature beats (RVST-PPB group); 36 with only RV outflow tract sustained or not sustained tachycardia (RVOTT group); 43 with RV monomorphic premature beats (RVMPB group). All the examinations were reevaluated in a blinded fashion for detecting myocardial adipose replacement (AR) and wall bulges or aneurysms. In RVST-PPB patients, no AR was observed in 9%; 1 RV region involvement, 0%; 2 regions, 4%; > or = 3 regions, 87%; left ventricle (LV), 15%. RVOTT patients: 28%, 53%, 14%, 5%, and 0% [corrected], respectively. RVMPB patients: 33%, 46%, 19%, 2%, and 0% [corrected], respectively. In CG, AR was observed in 11% (in RV outflow tract), RV bulges were detected in 75% [corrected] of RVST-PPB, 39% of RVOTT, and 14% of RVMPB patients, none of the CG; RV aneurysms in 33% of RVST-PPB patients, none of RVOTT patients, RVMBP patients, and CG. A significant difference among groups for RV and LV AR as well as RV bulges and aneurysms was found (p < 0.0001). In the direct comparisons, significant differences were found for: disease duration (RVST-PPB vs. RVMPB, p = 0.0396); RV AR (all the patients groups vs. CG, RVST-PPB vs. RVOTT or RVMPB, p < 0.0001); RV aneurysms (RVST-PPB vs. CG, RVST-PPB vs. RVOTT or RVMPB, p < 0.0002); bulges (all comparisons, p < 0.0174). AR is confirmed as a structural substrate in RV arrhythmias. Number and extension of MR abnormalities are correlated to different degrees of RV arrhythmias.

Author information

Author/s: Molinari, G (G); Sardanelli, F (F); Zandrino, F (F); Parodi, R C (RC); Bertero, G (G); Richiardi, E (E); Di Donna, P (P); Gaita, F (F); Masperone, M A (MA);

Affiliation: Department of Cardiology, University of Genoa, Italy. molinari(-atsign-)cardio.dimi.unige.it

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: International journal of cardiac imaging (Int J Card Imaging), published in NETHERLANDS. (Language: eng)

Reference: 2000-Apr; vol 16 (issue 2) : pp 105-15

Dates: Created 2000/12/05; Completed 2000/12/05; Revised 2006/11/15;

PMID: 10928345, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

ErratumIn: Int J Card Imaging 2000 Dec;16(6):485.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Aged Arrhythmogenic Right Ventricular Dysplasia - diagnosis; physiopathology Bundle-Branch Block - diagnosis; physiopathology Case-Control Studies Electrocardiography - methods Female Humans

Magnetic Resonance Imaging - methods Male Middle Aged Reference Values Retrospective Studies Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Tachycardia, Ventricular - diagnosis; physiopathology

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