Effects of methylphenidate on functional MRI blood-oxygen-level-dependent contrast.

Full Abstract

OBJECTIVE: The authors' goal was to determine potential hemodynamic consequences of methylphenidate on functional magnetic resonance imaging (MRI) blood-oxygen-level-dependent (BOLD) contrast. METHOD: BOLD and perfusion changes were recorded from the motor cortex of six healthy subjects while they performed flexion-extension movements of the right index finger (finger tapping) at varying rates before and after oral methylphenidate administration. RESULTS: Functional MRI signals increased monotonically with faster movement rates. Subjects' heart rates increased modestly after methylphenidate administration, but no changes in finger tapping performance or functional MRI signals were observed. CONCLUSIONS: Methylphenidate does not alter BOLD neural-hemodynamic coupling. Consequently, functional MRI can be used to map neural systems that subserve cognitive operations (e.g., attention and executive processes) in subjects taking methylphenidate.

Author information

Author/s: Rao, S M (SM); Salmeron, B J (BJ); Durgerian, S (S); Janowiak, J A (JA); Fischer, M (M); Risinger, R C (RC); Conant, L L (LL); Stein, E A (EA);

Affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee, 53226, USA. srao(-atsign-)mcw.edu

Grants: DA-09465 (Agency:NIDA NIH HHS) ; MH-51358 (Agency:NIMH NIH HHS) ; MH-57836 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: The American journal of psychiatry (Am J Psychiatry), published in UNITED STATES. (Language: eng)

Reference: 2000-Oct; vol 157 (issue 10) : pp 1697-9

Dates: Created 2000/10/12; Completed 2000/10/26; Revised 2007/11/14;

PMID: 11007731, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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