Research article summary (published 30 Mar 2001):

TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes.

Full Abstract

OBJECTIVE: Genetic variation in the tumor necrosis factor (TNF) receptor 2 gene (TNFRSF1B) has shown association with insulin resistance in type 2 diabetes, hypercholesterolemia, coronary artery disease, and essential hypertension. Here we tested the TNFRSF1B marker used in the latter studies in type 2 diabetes patients. RESEARCH DESIGN AND METHODS: A case-control study of a microsatellite marker with five alleles (CA13- CA17) in intron 4 of TNFRSF1B was performed in 357 well-characterized white patients and 183 healthy control subjects. RESULTS: The CA16 allele was associated with clinical neuropathy (frequency = 27% in 69 patients with the condition versus 16% in 230 subjects without the condition; chi2 = 9.0, P = 0.011; odds ratio = 2.1 [95% CI 1.2-3.8]). No association was seen with other complications or diabetes itself. The CA16 allele tracked with elevation plasma HDL cholesterol (1.3 +/- 0.2, 1.2 +/- 0.4, and 1.1 +/- 0.2 for CA16/CA16, CA16/-, and -/-, respectively; n = 9, 110, and 218, respectively; P = 0.009) and reduction in plasma glycosylated hemoglobin (6.6 +/- 0.3, 8.3 +/- 0.2, and 8.1 +/- 0.1 for CA16/CA16, CA16/-, and -/-, respectively; n = 9, 102, 205, respectively; P = 0.007) Significance remained after Bonferroni correction for multiple testing. CONCLUSIONS: Genetic variation in or near TNFRSF1B may predispose clinical neuropathy, reduced glycosylated hemoglobin, and increased HDL cholesterol in type 2 diabetes patients. The latter could be part of a protective response.

Author information

Author/s: Benjafield, A V (AV); Glenn, C L (CL); Wang, X L (XL); Colagiuri, S (S); Morris, B J (BJ);

Affiliation: Department of Physiology and Institute for Biomedical Research, the University of Sydney, Australia.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Diabetes care (Diabetes Care), published in United States. (Language: eng)

Reference: 2001-Apr; vol 24 (issue 4) : pp 753-7

Dates: Created 2001/04/23; Completed 2001/08/02; Revised 2008/11/21;

PMID: 11315843, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Albuminuria Alleles Australia Blood Pressure Case-Control Studies Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Cohort Studies Diabetes Mellitus, Type 2 - blood; genetics; physiopathology Diabetic Neuropathies - blood; genetics; physiopathology

European Continental Ancestry Group Female Genetic Markers Genetic Predisposition to Disease Genetic Variation Hemoglobin A, Glycosylated - analysis Humans Male Middle Aged Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor, Type II Triglycerides - blood

Associated Chemicals: Cholesterol, HDL (0) ; Cholesterol, LDL (0) ; Genetic Markers (0) ; Hemoglobin A, Glycosylated (0) ; Receptors, Tumor Necrosis Factor (0) ; Receptors, Tumor Necrosis Factor, Type II (0) ; TNFRSF1B protein, human (0) ; Triglycerides (0) ; Cholesterol (57-88-5)

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