Muscarinic dependence of nucleus basalis induced conditioned receptive field plasticity.

Full Abstract

Receptive field (RF) plasticity in primary auditory cortex of adult animals, specifically selective increased response to a tonal conditioned stimulus (CS) relative to other frequencies, can be induced both by behavioral conditioning and by pairing a tone with stimulation of the nucleus basalis (NB). This study determined whether cortical muscarinic receptors are necessary for NB-induced RF plasticity. Single units in layers II-IV were studied in Urethane anesthetized adult rats. The cortex was perfused with saline or saline+atropine sulfate. Conditioning, 30 trials of pairing a tone with NB stimulation, produced a significant CS-specific response increase (n=8). Local atropine blocked NB-induced RF plasticity, actually resulting in CS-specific response decrease (n=6). Therefore, NB-induced RF plasticity requires engagement of muscarinic receptors in auditory cortex.

Author information

Author/s: Miasnikov, A A (AA); McLin, D (D); Weinberger, N M (NM);

Affiliation: Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697-3800, USA.

Grants: DC 02938 (Agency:NIDCD NIH HHS) ; DC02346 (Agency:NIDCD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2001-May; vol 12 (issue 7) : pp 1537-42

Dates: Created 2001/06/04; Completed 2001/10/25; Revised 2007/11/14;

PMID: 11388444, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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