Research article summary (published 30 Jan 1999):

Lack of pharmacokinetic and pharmacodynamic interaction between rizatriptan and paroxetine.

Full Abstract

Rizatriptan is a potent, oral 5-HT(1B/1D) agonist with a rapid onset of action being investigated for the acute treatment of migraine. This study examined the clinical and pharmacolinetic interaction between rizatriptan and the selective serotonin reuptake inhibitor, paroxetine. In this two-period crossover study, 12 healthy young subjects (6 males and 6 females) received 1 mg rizatriptan following 14 days of treatment with placebo or paroxetine (20 mg once daily). Plasma was sampled for rizatriptan and N-monodesmethyl rizatriptan, a minor but active metabolite of rizatriptan. Safety evaluations included monitoring for adverse events, vital signs, and visual analog scale assessment of mood. Plasma levels of rizatriptan and N-monodesmethyl rizatriptan were not altered when rizatriptan was administered with paroxetine compared to the placebo. Clinically, coadministration of rizatriptan with paroxetine was well tolerated. Blood pressure, heart rate, and temperature changes during the observation period did not differ to a clinically significant degree when rizatriptan was administered with paroxetine compared to the placebo. No effects on mood occurred following treatment with the combination compared to rizatriptan alone. Adverse events following rizatriptan administration with paroxetine were similar to those reported when rizatriptan was given with the placebo.

Author information

Author/s: Goldberg, M R (MR); Lowry, R C (RC); Musson, D G (DG); Birk, K L (KL); Fisher, A (A); De Puy, M E (ME); Shadle, C R (CR);

Affiliation: Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial

Journal: Journal of clinical pharmacology (J Clin Pharmacol), published in United States. (Language: eng)

Reference: 1999-Feb; vol 39 (issue 2) : pp 192-9

Dates: Created 2001/09/20; Completed 2001/10/11; Revised 2005/11/17;

PMID: 11563413, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Affect - drug effects; physiology Analysis of Variance Area Under Curve Blood Pressure - drug effects; physiology Body Temperature - drug effects; physiology Confidence Intervals Cross-Over Studies Double-Blind Method Drug Interactions - physiology

Female Heart Rate - drug effects; physiology Humans Male Paroxetine - blood; pharmacokinetics; pharmacology Serotonin Agonists - blood; pharmacokinetics; pharmacology Serotonin Uptake Inhibitors - blood; pharmacokinetics; pharmacology Statistics, Nonparametric Triazoles - blood; pharmacokinetics; pharmacology Tryptamines

Associated Chemicals: Serotonin Agonists (0) ; Serotonin Uptake Inhibitors (0) ; Triazoles (0) ; Tryptamines (0) ; rizatriptan (145202-66-0) ; Paroxetine (61869-08-7)

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