Research article summary (published 25 Sep 2001):

The reelin pathway modulates the structure and function of retinal synaptic circuitry.

Full Abstract

The formation of synaptic connections requires the coordination of specific guidance molecules and spontaneous neuronal activity. The visual system has provided a useful model for understanding the role of these cues in shaping the precise connections from the neural retina to the brain. Here, we demonstrate that two essential genes in the Reelin signaling pathway function during the patterning of synaptic connectivity in the retina. Physiological studies of mice deficient in either reelin or disabled-1 reveal an attenuation of rod-driven retinal responses. This defect is associated with a decrease in rod bipolar cell density and an abnormal distribution of processes in the inner plexiform layer. These results imply that, in addition to its essential role during neuronal migration, the Reelin pathway contributes to the formation of neuronal circuits in the central nervous system.

Author information

Author/s: Rice, D S (DS); Nusinowitz, S (S); Azimi, A M (AM); Martínez, A (A); Soriano, E (E); Curran, T (T);

Affiliation: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Grants: F32 EY06972 (Agency:NEI NIH HHS) ; P30 CA21765 (Agency:NCI NIH HHS) ; R01 NS36558 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2001-Sep; vol 31 (issue 6) : pp 929-41

Dates: Created 2001/10/02; Completed 2001/12/04; Revised 2008/11/21;

PMID: 11580894, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adaptor Proteins, Signal Transducing Age Factors Animals Cell Adhesion Molecules, Neuronal - deficiency; genetics; physiology Cell Count Cell Movement Electroretinography Extracellular Matrix Proteins - deficiency; genetics; physiology Eye Proteins - genetics; physiology Interneurons - metabolism Mice

Mice, Inbred C3H Mice, Inbred C57BL Mice, Neurologic Mutants Nerve Tissue Proteins - genetics; physiology Receptors, LDL - physiology Receptors, Lipoprotein - physiology Retina - metabolism; ultrastructure Retinal Rod Photoreceptor Cells - pathology Serine Endopeptidases Synapses - physiology; ultrastructure Visual Pathways - physiology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Adaptor Proteins, Signal Transducing (0) ; Cell Adhesion Molecules, Neuronal (0) ; DAB1 protein, human (0) ; Extracellular Matrix Proteins (0) ; Eye Proteins (0) ; Nerve Tissue Proteins (0) ; Receptors, LDL (0) ; Receptors, Lipoprotein (0) ; VLDL receptor (0) ; apolipoprotein E receptor 2 (0) ; Serine Endopeptidases (EC 3.4.21.-) ; reelin protein (EC 3.4.21.-)

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