Research article summary (published 29 Sep 2001):

New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity.

Full Abstract

Three new acetophenone glucosides (4-6), three known aglycons (1-3), and a benzo-gamma-pyrone glucoside (7) were isolated from the CH(2)Cl(2), EtOAc, and BuOH extracts from the aerial parts of Helichrysum italicum. All the compounds tested showed antiinflammatory activity in a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema test, and the ID(50) value of compound 2, the most active compound, was determined.

Author information

Author/s: Sala, A (A); Recio, M C (MC); Giner, R M (RM); Máñez, S (S); Ríos, J L (JL);

Affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2001-Oct; vol 64 (issue 10) : pp 1360-2

Dates: Created 2001/10/26; Completed 2001/12/21; Revised 2006/11/15;

PMID: 11678669, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetophenones - chemistry; isolation & purification; pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry; isolation & purification; pharmacology Asteraceae - chemistry Benzopyrans - chemistry; isolation & purification; pharmacology Chromatography, Thin Layer Dose-Response Relationship, Drug Edema - chemically induced; drug therapy Glucosides - chemistry; isolation & purification; pharmacology Indomethacin - pharmacology Magnetic Resonance Spectroscopy

Magnetic Resonance Spectroscopy Mice Phenols - chemistry; isolation & purification; pharmacology Plant Extracts - chemistry; isolation & purification; pharmacology Plants, Medicinal - chemistry Spain Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Tetradecanoylphorbol Acetate beta-Glucosidase - metabolism

Associated Chemicals: 12-hydroxytremetone-12-O-beta-D-glucopyranoside (0) ; 3-(2-hydroxyethyl)acetophenone-4-O-beta-D-glucopyranoside (0) ; 3-(3-methyl-2-butenyl)acetophenone-4-O-beta-D-glucopyranoside (0) ; Acetophenones (0) ; Anti-Inflammatory Agents, Non-Steroidal (0) ; Benzopyrans (0) ; Glucosides (0) ; Phenols (0) ; Plant Extracts (0) ; Tetradecanoylphorbol Acetate (16561-29-8) ; Indomethacin (53-86-1) ; beta-Glucosidase (EC 3.2.1.21)

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