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Induction of multiple signaling loops by MuSK during neuromuscular synapse formation.
Full Abstract
At the neuromuscular junction, two motor neuron-derived signals have been implicated in the regulation of synaptogenesis. Neuregulin-1 is thought to induce transcription of acetylcholine receptor (AChR) genes in subsynaptic muscle nuclei by activating ErbB receptors. Neural agrin aggregates AChRs by activating the receptor tyrosine kinase MuSK. Here, we show that these two signals act sequentially. Agrin, by activating MuSK, induces the synthesis and aggregation of both MuSK and ErbB receptors. ErbB acts downstream of MuSK in synapse formation. In this way, MuSK activation leads to the establishment of a neuregulin-1-dependent signaling complex that maintains MuSK, ErbB, and AChR expression at the synapse of electrically active muscle fibers.
Author information
Author/s: Moore, C (C); Leu, M (M); Müller, U (U); Brenner, H R (HR);
Affiliation: Department of Physiology, University of Basel, 4051 Basel, Switzerland.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), published in United States. (Language: eng)
Reference: 2001-Dec; vol 98 (issue 25) : pp 14655-60
Dates: Created 2001/12/05; Completed 2002/01/10; Revised 2008/11/21;
PMID: 11717400, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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