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| Research article summary (published 30 Oct 2000): |
Perindopril.
Full Abstract
Perindopril is the newest angiotensin-converting enzyme inhibitor to be approved in the United States. It is indicated for the treatment of essential hypertension either alone or in combination with other antihypertensives, especially thiazide diuretics. Perindopril must be converted to perindoprilat, its active metabolite. The drug's prolonged duration of action allows for once daily administration. This article reviews clinical trials performed using perindopril alone and in combination to treat essential hypertension. The use of perindopril for congestive heart failure is reviewed. The influence of perindopril on arterial wall properties is discussed. Tolerability, drug interactions, and dosage and administration of the drug are reviewed.
Author information
Author/s: O'Loughlin, D C (DC); Chu, V L (VL); Singh, D (D);
Affiliation: Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA.
Journal and publication information
Publication Type: Journal Article; Review
Journal: Heart disease (Hagerstown, Md.) (Heart Dis), published in United States. (Language: eng)
Reference: -2000 Nov-Dec; vol 2 (issue 6) : pp 446-55
Dates: Created 2001/11/30; Completed 2001/12/18; Revised 2007/11/15;
PMID: 11728296, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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