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| Research article summary (published 29 Nov 2001): |
Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.
Full Abstract
The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the CA3 region of rat hippocampal slices. In addition, we have used LY382884 to study a novel synaptic mechanism. This antagonist substantially reduces frequency facilitation of mossy fibre synaptic transmission, monitored as either AMPA or NMDA receptor-mediated EPSCs. This suggests that GluR5-containing kainate receptors on mossy fibres function as autoreceptors to facilitate the synaptic release of L-glutamate, in a frequency-dependent manner.
Author information
Author/s: Lauri, S E (SE); Delany, C (C); J Clarke, V R (VR); Bortolotto, Z A (ZA); Ornstein, P L (PL); T R Isaac, J (J); Collingridge, G L (GL);
Affiliation: MRC Centre for Synaptic Plasticity, Department of Anatomy, Medical School, University of Bristol, BS8 1TD, Bristol, UK.
Journal and publication information
Publication Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuropharmacology (Neuropharmacology), published in England. (Language: eng)
Reference: 2001-Dec; vol 41 (issue 8) : pp 907-15
Dates: Created 2001/12/18; Completed 2002/03/26; Revised 2006/11/15;
PMID: 11747895, status: MEDLINE (last retrieved date: 2/18/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Excitatory Amino Acid Agonists (0) ; Isoxazoles (0) ; Propionates (0) ; Receptors, AMPA (0) ; Receptors, Kainic Acid (0) ; Receptors, Presynaptic (0) ; alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate (140158-50-5)Related articles
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