Research article summary (published 30 Jan 2002):

SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice.

Full Abstract

This study reports a series of spatial discrimination procedures in a Morris-type maze to investigate the effects of delta9-tetrahydrocannabinol (delta9-THC) on different phases of learning and memory in mice. Adult male mice were given training trails to find the submerged platform at a fixed location in the water maze adapted for mice. In additional experiments, mice were trained with the repeated acquisition procedure to test the working memory. Results indicate that delta9-THC (8 mg/kg i.p.) 30 min pretest impaired specifically the acquisition of spatial learning and the performance of mice in the working memory task, while consolidation and retrieval of a previously learned task were not affected. There was no evidence of motoric difficulty, as the number of quadrant line crossings was not decreased and no visible sign of sensorimotor disturbance was observed during swimming. Pretreatment with SR 141716A (1 mg/kg i.p.), a CB1 cannabinoid receptor antagonist, significantly prevented the learning deficits in the water maze. These findings show that delta9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors.

Author information

Author/s: Da, SilvaGeorgeE (S); Takahashi, Reinaldo N (RN);

Affiliation: Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), published in England. (Language: eng)

Reference: 2002-Feb; vol 26 (issue 2) : pp 321-5

Dates: Created 2002/01/30; Completed 2002/07/22; Revised 2007/10/17;

PMID: 11817511, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Dose-Response Relationship, Drug Male Maze Learning - drug effects; physiology Memory Disorders - chemically induced; prevention & control Mice Piperidines - pharmacology; therapeutic use

Psychotropic Drugs - adverse effects Pyrazoles - pharmacology; therapeutic use Reaction Time - drug effects; physiology Receptors, Cannabinoid Receptors, Drug - antagonists & inhibitors; physiology Spatial Behavior - drug effects; physiology Tetrahydrocannabinol - adverse effects; antagonists & inhibitors

Associated Chemicals: Piperidines (0) ; Psychotropic Drugs (0) ; Pyrazoles (0) ; Receptors, Cannabinoid (0) ; Receptors, Drug (0) ; rimonabant (158681-13-1) ; Tetrahydrocannabinol (1972-08-3)

Related articles

These are the highest related articles currently in the database:

• [Cannabis and cannabinoids as drugs] 27 Feb 2007
• Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. 4 May 2003
• Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. 13 Dec 2000
• Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. 30 Aug 2001
• Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A. 23 Aug 1995
• CB1 receptor antagonist precipitates withdrawal in mice exposed to Delta9-tetrahydrocannabinol. 30 May 1998
• Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation. 13 Dec 2001
• Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. 25 Jun 1997
• Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. 8 May 2004

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.