Parallels between cerebellum- and amygdala-dependent conditioning.

Full Abstract

Recent evidence from cerebellum-dependent motor learning and amygdala-dependent fear conditioning indicates that, despite being mediated by different brain systems, these forms of learning might use a similar sequence of events to form new memories. In each case, learning seems to induce changes in two different groups of neurons. Changes in the first class of cells are induced very rapidly during the initial stages of learning, whereas changes in the second class of cells develop more slowly and are resistant to extinction. So, anatomically distinct cell populations might contribute differentially to the initial encoding and the long-term storage of memory in these two systems.

Author information

Author/s: Medina, Javier F (JF); Repa, J Christopher (JC); Mauk, Michael D (MD); LeDoux, Joseph E (JE);

Affiliation: Howard Hughes Medical Institute, Department of Physiology, W.M. Keck Foundation Center for Integrative Neurobiology, University of California, 513 Parnassus Avenue, Room HSE-808, San Francisco, California 94143-0444, USA. jmedina(-atsign-)phy.ucsf.edu

Journal and publication information

Publication Type: Comparative Study; Journal Article; Review

Journal: Nature reviews. Neuroscience (Nat Rev Neurosci), published in England. (Language: eng)

Reference: 2002-Feb; vol 3 (issue 2) : pp 122-31

Dates: Created 2002/02/11; Completed 2002/03/01; Revised 2008/05/04;

PMID: 11836520, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

ErratumIn: Nat Rev Neurosci 2002 Mar;3(3):236.

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