Research article summary (published 30 Mar 2002):

Effect of 8-OH-DPAT on temporal discrimination following central 5-hydroxytryptamine depletion.

Full Abstract

The 5-hydroxytryptamine (5-HT)(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) alters performance in discrete-trials timing schedules. 5-HT(1A) receptors occur both presynaptically and postsynaptically, but it is not known which receptor population mediates the effects of 8-OH-DPAT on timing. Rats received intra-raphe injections of 5,7-dihydroxytryptamine (n=16) or sham lesions (n=14). They were trained in a discrete-trials psychophysical procedure in which levers were presented at a predetermined time after the onset of each trial (2.5, 7.5,., 47.5 s). A response on lever A was reinforced if lever presentation occurred < 25 s after trial onset; a response on lever B was reinforced if lever presentation occurred >25 s after trial onset. After 70 preliminary sessions, the rats received 8-OH-DPAT (25, 50, 100, 200 microg kg(-1) sc) and saline vehicle. The percentage of responses on lever B (%B) increased as a function of time from trial onset. Under the baseline (vehicle-treatment) condition, performance did not differ between the two groups. 8-OH-DPAT did not alter the indifference point (time corresponding to %B=50%), but dose-dependently increased the Weber fraction in both groups. Forebrain concentrations of 5-HT and 5-HIAA in the lesioned group were approximately 10% of control levels. The results suggest that the effect of 8-OH-DPAT on performance on discrete-trials timing schedules is mediated by postsynaptic 5-HT(1A) receptors.

Author information

Author/s: Body, S (S); Chiang, T-J (TJ); Mobini, S (S); Ho, M-Y (MY); Bradshaw, C M (CM); Szabadi, E (E);

Affiliation: Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Room B109, Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, UK.

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in United States. (Language: eng)

Reference: 2002-Apr; vol 71 (issue 4) : pp 787-93

Dates: Created 2002/03/12; Completed 2002/09/11; Revised 2003/11/14;

PMID: 11888569, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

5,7-Dihydroxytryptamine - toxicity 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Brain Chemistry - drug effects Conditioning, Operant - drug effects Discrimination (Psychology) - physiology Dopamine - metabolism Female Hydroxyindoleacetic Acid - metabolism

Norepinephrine - metabolism Rats Rats, Wistar Receptors, Presynaptic - drug effects Serotonin - physiology Serotonin Agents - toxicity Serotonin Agonists - pharmacology Synapses - physiology Time Perception - drug effects

Associated Chemicals: Receptors, Presynaptic (0) ; Serotonin Agents (0) ; Serotonin Agonists (0) ; 5,7-Dihydroxytryptamine (31363-74-3) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6) ; Hydroxyindoleacetic Acid (54-16-0) ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)

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