Research article summary (published 30 Mar 2002):

The synchronization of the human cortical working memory network.

Full Abstract

A verbal reasoning problem at the intersection of verbal working memory, problem-solving, and language comprehension was examined using event-related fMRI to distinguish differences in the differential timing of the response of the various cortical regions that compose the working memory network. Problems were developed such that the process demand as well as the timing of the manipulation of the contents of working memory (i.e., a demanding computation) was varied. Activation was observed in several regions including the dorsolateral prefrontal cortex, the inferior frontal gyrus, and the parietal lobe. Examination of the MR amplitude response revealed that the regions do not all activate simultaneously; instead, their activation time courses reveal differential responses that correspond to their theoretical processing role in the problem-solving task. The coordination of cortical area responses reveals how the various cortical regions synchronize and collaborate in order to accomplish a given cognitive function. (C)2002 Elsevier Science (USA).

Author information

Author/s: Newman, Sharlene D (SD); Just, Marcel Adam (MA); Carpenter, Patricia A (PA);

Affiliation: Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

Grants: MH-00661 (Agency:NIMH NIH HHS) ; MH-00662 (Agency:NIMH NIH HHS) ; MH-29617 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)

Reference: 2002-Apr; vol 15 (issue 4) : pp 810-22

Dates: Created 2002/03/21; Completed 2002/05/30; Revised 2007/11/15;

PMID: 11906222, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Attention - physiology Brain Mapping Cerebral Cortex - physiology Cortical Synchronization Female Hemodynamics - physiology Humans Image Enhancement

Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Mental Recall - physiology Nerve Net - physiology Problem Solving - physiology Reaction Time - physiology Reference Values Verbal Learning - physiology

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