Research article summary (published 27 Feb 2002):

Synaptic depression improves coincidence detection in the nucleus laminaris in brainstem slices of the chick embryo.

Full Abstract

Neurons in the nucleus laminaris detect the coincidence of binaural signals, and are the first neurons to calculate the interaural time difference for the sound source localization in birds. In this paper, we have studied contributions of synaptic depression to the coincidence detection in the nucleus laminaris in a slice preparation of the chick embryo (E16-18), using the whole-cell patch recording technique. Under voltage clamp, EPSCs decreased progressively in their amplitude during the course of tetanic stimuli. This synaptic depression was primarily ascribed to the reduction of transmitter release from the presynaptic terminal, because the depression was decreased by reducing transmitter release with 2.5 microm Cd2+ but was not affected by reducing desensitization of postsynaptic AMPA receptors with 20 microm cyclothiazide. Under current clamp, trains of 10 stimuli of 100 Hz were applied bilaterally with changing the time intervals systematically between both sides. Response window, defined as the time interval corresponding to the half-maximum firing probability, was narrowed during the course of the stimulus train, and this occurred in parallel with a decrease in the EPSP amplitude. In addition, the reduction of the EPSP amplitude due to 2.5 microm Cd2+ or 2 microm CNQX improved the accuracy of coincidence detection. These results indicate that the synaptic depression may improve the coincidence detection in the chick laminaris neurons.

Author information

Author/s: Kuba, Hiroshi (H); Koyano, Konomi (K); Ohmori, Harunori (H);

Affiliation: Department of Physiology, Faculty of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The European journal of neuroscience (Eur J Neurosci), published in France. (Language: eng)

Reference: 2002-Mar; vol 15 (issue 6) : pp 984-90

Dates: Created 2002/03/28; Completed 2002/06/12; Revised 2006/11/15;

PMID: 11918658, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - drug effects; physiology Animals Antihypertensive Agents - pharmacology Auditory Pathways - cytology; drug effects; physiology Benzothiadiazines - pharmacology Cadmium - pharmacology Chick Embryo Chickens - anatomy & histology; physiology Cochlear Nucleus - cytology; drug effects; physiology

Dendrites - drug effects; physiology Electric Stimulation Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects; physiology Neural Inhibition - drug effects; physiology Presynaptic Terminals - drug effects; physiology Receptors, AMPA - agonists; antagonists & inhibitors; metabolism Sound Localization - drug effects; physiology Synaptic Transmission - drug effects; physiology

Associated Chemicals: Antihypertensive Agents (0) ; Benzothiadiazines (0) ; Excitatory Amino Acid Antagonists (0) ; Receptors, AMPA (0) ; cyclothiazide (2259-96-3) ; Cadmium (7440-43-9)

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