Research article summary (published 2 Mar 2002):

AMPA receptor trafficking and synaptic plasticity.

Full Abstract

Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.

Author information

Author/s: Malinow, Roberto (R); Malenka, Robert C (RC);

Affiliation: Cold Spring Harbor Laboratory, New York 11724, USA. malinow(-atsign-)cshl.org

Journal and publication information

Publication Type: Journal Article; Review

Journal: Annual review of neuroscience (Annu Rev Neurosci), published in United States. (Language: eng)

Reference: 2002-; vol 25 (issue ) : pp 103-26

Dates: Created 2002/06/07; Completed 2002/10/10; Revised 2004/11/17;

PMID: 12052905, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Hippocampus - cytology; metabolism Humans Long-Term Potentiation - physiology Memory - physiology

Neural Inhibition - physiology Neuronal Plasticity - physiology Protein Transport - physiology Receptors, AMPA - metabolism Synaptic Transmission - physiology

Associated Chemicals: Receptors, AMPA (0)

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