Research article summary (published 10 Jun 2002):

Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.

Full Abstract

The present study investigated the involvement of the serotonin (5-hydroxytryptamine, 5-HT) neuronal system in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory in the eight-arm radial maze in rats. Delta(9)-Tetrahydrocannabinol (6 mg/kg, i.p.), which impairs spatial memory, significantly increased the 5-HT content in the ventral hippocampus. A microdialysis study showed that Delta(9)-tetrahydrocannabinol (6 mg/kg, i.p.) decreased 5-HT release in the ventral hippocampus. The 5-HT precursor, 5-hydroxy-L-tryptophan (5-HTP; 50 mg/kg, i.p.), the 5-HT re-uptake inhibitor, clomipramine (0.01 and 0.1 mg/kg, i.p.), the 5-HT receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT; 0.01 and 0.03 mg/kg, i.p.), and the 5-HT(2) receptor agonist, 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (DOI; 10 microg/kg, i.p.), significantly attenuated the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory. These results suggest that the 5-HT neuronal system may be involved in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.

Author information

Author/s: Egashira, Nobuaki (N); Mishima, Kenichi (K); Katsurabayashi, Shutaro (S); Yoshitake, Tomohiro (T); Matsumoto, Yoshiaki (Y); Ishida, Junichi (J); Yamaguchi, Masatoshi (M); Iwasaki, Katsunori (K); Fujiwara, Michihiro (M);

Affiliation: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: European journal of pharmacology (Eur J Pharmacol), published in Netherlands. (Language: eng)

Reference: 2002-Jun; vol 445 (issue 3) : pp 221-9

Dates: Created 2002/06/24; Completed 2003/01/03; Revised 2006/11/15;

PMID: 12079687, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

5-Hydroxytryptophan - pharmacology Animals Hippocampus - drug effects; metabolism Male Maze Learning - drug effects; physiology Memory - drug effects; physiology Neurons - drug effects; metabolism

Rats Rats, Wistar Serotonin - metabolism Serotonin Agonists - pharmacology Serotonin Uptake Inhibitors - pharmacology Spatial Behavior - drug effects; physiology Tetrahydrocannabinol - pharmacology

Associated Chemicals: Serotonin Agonists (0) ; Serotonin Uptake Inhibitors (0) ; Tetrahydrocannabinol (1972-08-3) ; Serotonin (50-67-9) ; 5-Hydroxytryptophan (56-69-9)

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