Research article summary (published 30 Jul 2002):

Antidiabetic and hypolipidemic activity of Helicteres isora in animal models.

Full Abstract

Helicteres isora (Sterculiaceae) root juice has been used in the treatment of diabetes by several ethnic groups in different parts of India. A program was initiated to elucidate the scientific basis for the antidiabetic activity of H. isora. Ethanolic extract of H. isora root caused significant reduction in plasma glucose, triglyceride and insulin levels at 300 mg/kg dose after 9 days of administration to insulin resistant and diabetic C57BL/KsJdb/db mice. In normoglycemic and mildly hypertriglyceridemic Swiss albino mice, the extract also showed significant reduction in plasma triglyceride and insulin levels, without affecting plasma glucose level. An ethanolic extract showed activity distinctly different from glybenclamide and acarbose but similar to troglitazone in these models. In high fat fed hamster model, the extract showed significant reduction in plasma lipid levels. In order to identify the active pharmacophore, the ethanolic extract was further subjected to sequential partitioning with low, medium and high polarity solvents, which yielded a semipurified fraction having both euglycemic and lipid-lowering activity. Our study suggests that the extract of H. isora has insulin-sensitizing and hypolipidemic activity and has the potential for use in the treatment of type-2 diabetes.

Author information

Author/s: Chakrabarti, Ranjan (R); Vikramadithyan, Reeba K (RK); Mullangi, Ramesh (R); Sharma, V M (VM); Jagadheshan, H (H); Rao, Y N (YN); Sairam, P (P); Rajagopalan, R (R);

Affiliation: Discovery Biology, Dr Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India. ranjanchakrabarti(-atsign-)drreddys.com

Journal and publication information

Publication Type: Journal Article

Journal: Journal of ethnopharmacology (J Ethnopharmacol), published in Ireland. (Language: eng)

Reference: 2002-Aug; vol 81 (issue 3) : pp 343-9

Dates: Created 2002/07/19; Completed 2003/02/11; Revised 2008/11/21;

PMID: 12127235, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Blood Glucose - analysis Cell Line Cricetinae Diabetes Mellitus, Experimental - blood; drug therapy Dietary Fats - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Humans Hypoglycemic Agents - pharmacology; therapeutic use India Insulin - blood Lipids - blood

Lipids - blood Male Mesocricetus Mice Phytotherapy Plant Extracts - pharmacology; therapeutic use Plant Roots - chemistry Plants, Medicinal - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Sterculiaceae - chemistry Transcription Factors - metabolism Transcriptional Activation - drug effects Triglycerides - blood

Associated Chemicals: Blood Glucose (0) ; Dietary Fats (0) ; Hypoglycemic Agents (0) ; Lipids (0) ; Plant Extracts (0) ; Receptors, Cytoplasmic and Nuclear (0) ; Transcription Factors (0) ; Triglycerides (0) ; Insulin (11061-68-0)

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