Research article summary (published 7 Aug 2002):

Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice.

Full Abstract

We previously showed that rosmarinic acid from the leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba) has antidepressive-like activity. The aim of the present study was to examine (i) whether caffeic acid, a major metabolite of rosmarinic acid, also has antidepressive-like activity, and (ii) whether these substances inhibit either the uptake of monoamines to synaptosomes or mitochondrial monoamine oxidase activity. Rosmarinic acid (2 mg/kg, i.p.) and caffeic acid (4 mg/kg, i.p.) each significantly reduced the duration of immobility in the forced swimming test in mice. In contrast, neither substance, at doses that produced a significant reduction in the immobile response in the forced swimming test, affected spontaneous motor activity. These results indicate that, like rosmarinic acid, caffeic acid also possesses antidepressive-like activity. In neuropharmacological studies, neither rosmarinic acid (10 x (-9)-10 x (-3) M) nor caffeic acid (10 x (-9)-10 x (-3) M) affected either the uptake of monoamines to synaptosomes or mitochondrial monoamine oxidase activity in the mouse brain. These results suggest that both caffeic acid and rosmarinic acid may produce antidepressive-like activity via some mechanism(s) other than the inhibition of monoamine transporters and monoamine oxidase.

Author information

Author/s: Takeda, Hiroshi (H); Tsuji, Minoru (M); Inazu, Masato (M); Egashira, Toru (T); Matsumiya, Teruhiko (T);

Affiliation: Department of Pharmacology and Intractable Diseases Research Center (Division of Drug Research and Devlopment), Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, 160-8402, Tokyo, Japan. ht0417(-atsign-)tokyo-med.ac.jp

Journal and publication information

Publication Type: Journal Article

Journal: European journal of pharmacology (Eur J Pharmacol), published in Netherlands. (Language: eng)

Reference: 2002-Aug; vol 449 (issue 3) : pp 261-7

Dates: Created 2002/08/08; Completed 2003/02/13; Revised 2006/11/15;

PMID: 12167468, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antidepressive Agents - pharmacology Biogenic Monoamines - metabolism Caffeic Acids - pharmacology Cinnamates - pharmacology Depression - drug therapy; psychology Depsides Dopamine - metabolism Male

Mice Mice, Inbred ICR Mitochondria - drug effects; metabolism Monoamine Oxidase - metabolism Motor Activity - drug effects Norepinephrine - metabolism Serotonin - metabolism Swimming - psychology Synaptosomes - drug effects; metabolism

Associated Chemicals: Antidepressive Agents (0) ; Biogenic Monoamines (0) ; Caffeic Acids (0) ; Cinnamates (0) ; Depsides (0) ; caffeic acid (331-39-5) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6) ; rosmarinic acid (537-15-5) ; Monoamine Oxidase (EC 1.4.3.4)

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