[Studies on antitussive, antiasthmatic, expectorant and anti-inflammatory effects of Jin'an kechuan granules]

Full Abstract

OBJECTIVE: To study the pharmacologic effect of Jin'an Kechuan granules. METHOD: Routine antitussive, antiasthmatic and expectorant methods were used. RESULT: Jin'an Kechuan granules in the doses of 16, 8, 4 g.kg-1 ig could significantly decrease the frequency of cough caused by ammonia water in mice, and increase the secretion of phenol red from mouse tracheas in a dose-dependent manner. The granules also help increase the threshold voltage to induce cats to cough, prolong the latent period of asthma induced by histamine and acetylcholine mixture, and antagonize the contraction of isolated trachea strips induced by histamine and acetylcholine in guinea pigs. Jin'an Kechuan granules had inhibitory effects on common bacteria in the respiratory tract as well as on the swelling of acute inflammation in mice and rats. CONCLUSION: Jin'an Kechuan granules have antitussive, antiasthmatic, expectorant and anti-inflammatory, antibacterial effects.

Author information

Author/s: Chen, G L (GL); Wang, Y (Y); Wang, Q M (QM); Liu, C (C); Cheng, H J (HJ); Han, L (L);

Affiliation: Department of Pharmacology, Anhui College of TCM, Anhui, Hefei 230038, China.

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi), published in China. (Language: chi)

Reference: 2000-Feb; vol 25 (issue 2) : pp 107-10

Dates: Created 2002/09/05; Completed 2003/01/31; Revised 2008/02/06;

PMID: 12212071, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Anti-Asthmatic Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antitussive Agents - therapeutic use
Asthma - drug therapy
Cats
Cough - drug therapy
Drug Combinations

Drug Combinations
Drugs, Chinese Herbal - therapeutic use
Expectorants - therapeutic use
Guinea Pigs
Mice
Phytotherapy
Plants, Medicinal
Rats

Associated Chemicals: Anti-Asthmatic Agents (0) ; Anti-Inflammatory Agents, Non-Steroidal (0) ; Antitussive Agents (0) ; Drug Combinations (0) ; Drugs, Chinese Herbal (0) ; Expectorants (0)

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