Research article summary (published 30 Oct 2002):

Insulin lispro therapy in pregnancies complicated by type 1 diabetes mellitus.

Full Abstract

OBJECTIVE: To compare the efficacy and safety of preprandial administration of rapid-acting lispro analogue with regular short-acting insulin to pregnant women with type 1 diabetes. STUDY DESIGN: Open randomised multicentre study. Women were treated with multiple insulin injections aiming at normoglycaemia. Blood glucose was determined six times daily, HbA(1c) every 4 weeks. Diurnal profiles of blood glucose were analysed at gestational week 14 and during the study period at weeks 21, 28 and 34. PARTICIPANTS: 33 pregnant women with type 1 DM were randomised to treatment with lispro insulin (n=16) or regular insulin (n=17). RESULTS: Blood glucose was significantly lower (P<0.01) after breakfast in the lispro group, while there were no significant group differences in glycemic control during the rest of the day. Severe hypoglycaemia occurred in two patients in the regular group but biochemical hypoglycaemia (blood glucose <3.0 mmol/l) was more frequent in the lispro than in the regular group (5.5 vs. 3.9%, respectively). HbA(1c) values at inclusion were 6.5 and 6.6% in the lispro and regular group respectively. HbA(1c) values declined during the study period and were similar in both groups. There was no perinatal mortality. Complications during pregnancy, route of delivery and foetal outcome did not differ between the groups. Retinopathy progressed in both groups, one patient in the regular group developed proliferative retinopathy. CONCLUSION: The results suggest that it is possible to achieve at least as adequate glycemic control with lispro as with regular insulin therapy in type 1 diabetic pregnancies.

Author information

Author/s: Persson, B (B); Swahn, M-L (ML); Hjertberg, R (R); Hanson, U (U); Nord, E (E); Nordlander, E (E); Hansson, L-O (LO);

Affiliation: Department of Pediatrics, Karolinska Hospital, 171 76 Stockholm, Sweden. bengt.persson(-atsign-)swipnet.se

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial

Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract), published in Ireland. (Language: eng)

Reference: 2002-Nov; vol 58 (issue 2) : pp 115-21

Dates: Created 2002/09/05; Completed 2003/04/23; Revised 2006/11/15;

PMID: 12213353, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Blood Glucose - drug effects; metabolism Diabetes Mellitus, Type 1 - drug therapy Diabetic Angiopathies - epidemiology Diabetic Retinopathy - epidemiology Drug Administration Schedule Female Hemoglobin A, Glycosylated - metabolism

Humans Hypoglycemic Agents - administration & dosage; therapeutic use Infant, Newborn Insulin - administration & dosage; analogs & derivatives; therapeutic use Parity Pregnancy Pregnancy Outcome Pregnancy in Diabetics - drug therapy

Associated Chemicals: Blood Glucose (0) ; Hemoglobin A, Glycosylated (0) ; Hypoglycemic Agents (0) ; Insulin (11061-68-0) ; insulin, neutral (12584-58-6) ; insulin LISPRO (133107-64-9)

Related articles

These are the highest related articles currently in the database:

• [Can education duning pregnancy improve the perinatal outcome in diabetic pregnancies?] 30 Dec 2003
• Insulin lispro therapy in pregnancies complicated by type 1 diabetes: glycemic control and maternal and fetal outcomes. 29 Apr 2003
• Insulin-dependent diabetes mellitus in which glycemic control was improved during pregnancy but deteriorated after delivery with the occurrence of postpartum thyrotoxicosis: a case report. 30 Aug 1991
• Insulin lispro and the development of proliferative diabetic retinopathy during pregnancy. 29 Apr 1999
• Clinical outcomes of pregnancy in women with type 1 diabetes(1). 30 Mar 2002
• [The frequency of mild and severe fetal malformations in diabetic women with high values of glycosilated hemoglobin in early pregnancy] 30 Dec 2004
• Fetal growth in women managed with insulin pump therapy compared to conventional insulin. 12 Nov 2007
• [The influence of pregnancy on progression of diabetic retinopathy] 30 Dec 2006
• [Insulin-dependent diabetes and pregnancy. A model of coordinated approach] 30 Dec 1985

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.