Research article summary (published 17 Dec 2002):

Glycobiology of the synapse: the role of glycans in the formation, maturation, and modulation of synapses.

Full Abstract

Synapses, which are the fundamental functional unit of the nervous system, are considered to be highly specialized cell adhesion structures. Studies since the 1960s demonstrated that various carbohydrates and glycoproteins are expressed in synapses in the central and peripheral nervous system. Although the functional roles of these synaptic carbohydrates and glycoproteins remain to be determined, rapidly accumulating data suggest that they may play critical roles in the formation, maturation, and functional modulation of synapses.

Author information

Author/s: Yamaguchi, Yu (Y);

Affiliation: Neurobiology Program, The Burnham Institute, La Jolla, CA 92037, USA. yyamaguchi(-atsign-)burnham.org

Journal and publication information

Publication Type: Journal Article; Review

Journal: Biochimica et biophysica acta (Biochim Biophys Acta), published in Netherlands. (Language: eng)

Reference: 2002-Dec; vol 1573 (issue 3) : pp 369-76

Dates: Created 2002/11/05; Completed 2003/01/10; Revised 2006/11/15;

PMID: 12417420, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Agrin - metabolism Animals Central Nervous System - metabolism; physiology Glycosylation Heparan Sulfate Proteoglycans - metabolism Heparitin Sulfate - metabolism Membrane Glycoproteins - metabolism

Membrane Glycoproteins - metabolism Neuromuscular Junction - metabolism; physiology Polysaccharides - metabolism; physiology Proteoglycans - metabolism Sialic Acids - metabolism Synapses - physiology Syndecan-2

Associated Chemicals: Agrin (0) ; Heparan Sulfate Proteoglycans (0) ; Membrane Glycoproteins (0) ; Polysaccharides (0) ; Proteoglycans (0) ; Sialic Acids (0) ; polysialic acid (0) ; Syndecan-2 (149769-25-5) ; Heparitin Sulfate (9050-30-0)

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