Research article summary (published 30 Dec 2001):

A tumor cell growth inhibitor from Saposhnikovae divaricata.

Full Abstract

In the present study, we tested ethanolic extracts from 10 Chinese herbs for their effects on K562, Raji, Wish, HeLa, Calu-1, and Vero tumor cells proliferation. On a percentage basis, panaxynol purified from Saposhnikovae divaricata had the highest inhibitory activity on various tumor cells proliferation. Cell-cycle analysis indicated that panaxynol arrested the cell cycle progression of tumor cells from the G1 transition to the S phase. In an attempt to further localize the point in the cell cycle where arrest occurred, gene expression of cyclin E, a key regulatory event leading to the G1/S boundary was examined. Results indicated that the levels of cyclin E mRNA in various tumor cells were decreased by panaxynol. Thus, the suppressant effects of panaxynol on proliferation of various tumor cells appeared to be mediated, at least in part, through impairments of cyclin E mRNA levels and arresting cell cycle progression in the cells.

Author information

Author/s: Kuo, Yuh-Chi (YC); Lin, Yun-Lian (YL); Huang, Cheng-Po (CP); Shu, Jia-Wei (JW); Tsai, Wei-Jern (WJ);

Affiliation: National Research Institute of Chinese Medicine, Department of Biology, Fu Jen University, Taipei, Taiwan, ROC.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Cancer investigation (Cancer Invest), published in United States. (Language: eng)

Reference: 2002-; vol 20 (issue 7-8) : pp 955-64

Dates: Created 2002/11/26; Completed 2002/12/12; Revised 2006/11/15;

PMID: 12449728, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alkynes Antineoplastic Agents - pharmacology; therapeutic use Apiaceae - chemistry Cell Cycle - drug effects Cell Division - drug effects Cell Survival - drug effects Cyclin E - genetics; metabolism DNA Primers - chemistry Diynes

Diynes Drugs, Chinese Herbal - pharmacology Fatty Alcohols - isolation & purification; pharmacology G1 Phase - drug effects Humans Plant Extracts - pharmacology Polymerase Chain Reaction RNA, Messenger - metabolism Tumor Cells, Cultured - drug effects; metabolism

Associated Chemicals: Alkynes (0) ; Antineoplastic Agents (0) ; Cyclin E (0) ; DNA Primers (0) ; Diynes (0) ; Drugs, Chinese Herbal (0) ; Fatty Alcohols (0) ; Plant Extracts (0) ; RNA, Messenger (0) ; falcarinol (21852-80-2)

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