Hypoglycaemic activity of Alpinia galanga rhizome and its extracts in rabbits.

Full Abstract

This investigation was carried out to study effects of Alpinia galanga rhizome on blood glucose levels. In normal rabbits, powdered rhizome and its methanol and aqueous extracts significantly lowered the blood glucose. Gliclazide also produced a significant decrease in blood glucose in the rabbits. In alloxan-diabetic rabbits, A. galanga and its methanol and aqueous extracts did not produce significant reduction in blood glucose. The hypoglycaemic effect of A. galanga in normal rabbits was comparable to gliclazide. The rhizome was found to contain high levels of certain minerals. Acute toxicity and behavioral studies revealed no visible signs of toxicity and any abnormal behavior in rabbits even at high doses. It is concluded that A. galanga produces fall in blood glucose levels in normal rabbits and the principles, both organic and inorganic, are extractable in methanol and water. Copyright 2002 Elsevier Science B.V.

Author information

Author/s: Akhtar, M S (MS); Khan, M A (MA); Malik, M T (MT);

Affiliation: Postgraduate Medical Institute, Lahore, Pakistan. drmsakhtar(-atsign-)hotmail.com

Journal and publication information

Publication Type: Journal Article

Journal: Fitoterapia (Fitoterapia), published in Netherlands. (Language: eng)

Reference: 2002-Dec; vol 73 (issue 7-8) : pp 623-8

Dates: Created 2002/12/19; Completed 2003/04/30; Revised 2008/11/21;

PMID: 12490221, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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