Diabetes mellitus as a contributor to the risk of acute myocardial infarction.

Full Abstract

The risk of nonfatal acute myocardial infarction (AMI) has been studied in relation to diabetes and other risk factors, combining data from three Italian case-control studies including 1,737 cases with nonfatal AMI and 2,317 controls in hospital for acute diseases unrelated to AMI risk factors. The multivariate odds ratio (OR) of AMI for diabetes was 2.3 (95% confidence interval, 1.8-2.9); the association with AMI risk was apparently stronger in patients diagnosed with diabetes when aged <40 years (OR 2.9), and in women (OR 4.4). When the combined effect of diabetes and other known risk factors on the risk of AMI was considered, compared to nondiabetic subjects with each factor at the lowest risk level, the OR for diabetic subjects was 4.7 in smokers, 2.8 in heavy coffee drinkers, 2.7 in those with higher body mass index, 3.4 in patients with high cholesterol levels, 3.3, 4.3, and 2.7 for diabetic subjects with history of hyperlipidemia, hypertension, and obesity, respectively, and 4.3 for those with a family history of AMI in first degree relatives. The association of each risk factor was much stronger in diabetic women. Preventive measures to reduce the prevalence of each additional risk factors in diabetic subjects could led to a substantial reduction of risk of AMI.

Author information

Author/s: Tavani, Alessandra (A); Bertuzzi, Michaela (M); Gallus, Silvano (S); Negri, Eva (E); La Vecchia, Carlo (C);

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy. tavani(-atsign-)marionegri.it

Journal and publication information

Publication Type: Journal Article; Meta-Analysis; Multicenter Study; Research Support, Non-U.S. Gov't

Journal: Journal of clinical epidemiology (J Clin Epidemiol), published in England. (Language: eng)

Reference: 2002-Nov; vol 55 (issue 11) : pp 1082-7

Dates: Created 2002/12/31; Completed 2003/02/20; Revised 2007/11/15;

PMID: 12507671, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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