Bisphenol A levels in human urine.

Full Abstract

The estrogenic effects of bisphenol A (BPA) have been reported in human cells (E-screen assays) and in (italic)in vivo(/italic) studies of rodents, although the latter reports remain controversial, as do the exposure levels and adverse health effects of BPA in humans. In this study we report on an analytical high-performance liquid chromatography/fluorescence method for BPA and its conjugate in human urine and on the application of this method in two student cohorts. Urine, along with information on smoking, alcohol intake, and coffee/tea consumption, was collected in two different years from two different groups of university students, 50 in 1992 and 56 in 1999. Overall, the urinary BPA levels in the students in 1992 were significantly higher than were those in 1999. The BPA levels were also positively correlated with coffee and tea consumption in the 1992 cohort but not in the 1999 cohort. We speculate that recent changes made in Japan regarding the interior coating of cans used to package these beverages may partly explain these findings.

Author information

Author/s: Matsumoto, Akiko (A); Kunugita, Naoki (N); Kitagawa, Kyoko (K); Isse, Toyohi (T); Oyama, Tsunehiro (T); Foureman, Gary L (GL); Morita, Masatoshi (M); Kawamoto, Toshihiro (T);

Affiliation: Department of Environmental Health, University of Occupational and Environmental Health, Kitakyusyu, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Environmental health perspectives (Environ Health Perspect), published in United States. (Language: eng)

Reference: 2003-Jan; vol 111 (issue 1) : pp 101-4

Dates: Created 2003/01/07; Completed 2003/10/15; Revised 2008/11/20;

PMID: 12515686, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Associated Chemicals: Acetonitriles (0) ; Coffee (0) ; Estrogens, Non-Steroidal (0) ; Furans (0) ; Phenols (0) ; Tea (0) ; tetrahydrofuran (109-99-9) ; acetonitrile (75-05-8) ; bisphenol A (80-05-7)

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