Research article summary (published 29 Nov 2002):

Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin A hybrid peptide.

Full Abstract

Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.

Author information

Author/s: Wade, David (D); Flock, Jan-Ingmar (JI); Edlund, Charlotta (C); Löfving-Arvholm, Ingegerd (I); Sällberg, Matti (M); Bergman, Tomas (T); Silveira, Angela (A); Unson, Cecille (C); Rollins-Smith, Louise (L); Silberring, Jerzy (J); Richardson, Malcom (M); Kuusela, Pentti (P); Lankinen, Hilkka (H);

Affiliation: Karolinska Institutet, Department of Microbiology, Pathology, and Immunology, Division of Clinical Virology, F-68, Huddinge University Hospital, S-14186 Huddinge, Sweden.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Journal: Protein and peptide letters (Protein Pept Lett), published in Netherlands. (Language: eng)

Reference: 2002-Dec; vol 9 (issue 6) : pp 533-43

Dates: Created 2003/01/29; Completed 2003/07/15; Revised 2009/11/03;

PMID: 12553862, status: MEDLINE (last retrieved date: 11/3/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Anti-Bacterial Agents - chemistry; pharmacology Antifungal Agents - chemistry Antimicrobial Cationic Peptides - chemistry; pharmacology Biological Assay Hemolysis - drug effects

Humans Peptides - chemistry Proteins - chemistry; pharmacology Recombinant Fusion Proteins - chemistry; pharmacology Structure-Activity Relationship

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Anti-Bacterial Agents (0) ; Antifungal Agents (0) ; Antimicrobial Cationic Peptides (0) ; Peptides (0) ; Proteins (0) ; Recombinant Fusion Proteins (0) ; temporin (0) ; cecropin A (80451-04-3)

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