Research article summary (published 30 Jul 2000):

Hypoglycemic effect of aqueous extract of Enicostemma littorale Blume (chhota chirayata) on alloxan induced diabetes mellitus in rats.

Full Abstract

The whole plant aqueous extract of E. littorale was tested for its hypoglycemic activity on normoglycemic, hyperglycemic and alloxan induced diabetic rats. Blood sugar lowering activity was not observed in normoglycemic and glucose loaded hyperglycemic rats in the short time experiment. But in case of diabetic rats, the fall of blood sugar after 30 days treatment with the aqueous extract was found to be significant (P < 0.001). The decrease in the plasma glucose level was accompanied with decrease in the level of glycosylated haemoglobin and glucose-6-phosphatase activity in liver. The potent anti-diabetic properties of E. littorale has been reported for the first time.

Author information

Author/s: Vijayvargia, R (R); Kumar, M (M); Gupta, S (S);

Affiliation: Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Baroda 390 002, India. vijayravi(-atsign-)hotmail.com

Journal and publication information

Publication Type: Journal Article

Journal: Indian journal of experimental biology (Indian J Exp Biol), published in India. (Language: eng)

Reference: 2000-Aug; vol 38 (issue 8) : pp 781-4

Dates: Created 2003/01/31; Completed 2003/03/04; Revised 2003/11/14;

PMID: 12557910, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alloxan Animals Blood Glucose - analysis Diabetes Mellitus, Experimental - blood Hemoglobin A, Glycosylated - analysis

Hemoglobin A, Glycosylated - analysis Hypoglycemic Agents - pharmacology Male Plant Extracts - pharmacology Rats

Associated Chemicals: Blood Glucose (0) ; Hemoglobin A, Glycosylated (0) ; Hypoglycemic Agents (0) ; Plant Extracts (0) ; Alloxan (50-71-5)

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