Research article summary (published 29 Nov 1999):

[Angiotensin II regulates the expression of collagens in rat heart]

Full Abstract

OBJECTIVE: To testify the effect of angiotensin (Agn) II on the regulation and expression of collagen I, III genes in rat heart as well as the influence of DMP811 (a novel nonpeptide selective angiotension type 1 antagonist) on the effect of Ang II. METHODS: Six-week-old male SD rats with osmotic minipump subcutaneously containing either Ang II or saline were used. (1) Saline-infused(control) group (n = 6), (2) Ang II-infused group (n = 6). (3) Ang II-infused and DMP811-treated (3 mg.kg-1.d-1, by gavage) group (n = 6). Ang II (200 ng.kg-1.min-1) or saline was continuously infused for 1 week. After extraction of cardiac total RNA, the levels of collagen I, III mRNA and proteins were measured with RT-PCR and Sirius red staining respectively. RESULTS: Cardiac weight, cardiac weight/body weight radio, the mRNA levels of collagen I, III were increased by (4.7 +/- 0.4)%, (4.9 +/- 0.9)%, (22.0 +/- 4.7)% and (20.6 +/- 4.9)% respectively, in group 2 compared with those in group 1. The analysis of collagen on Sirius red-stained sections showed that Ang II increased the deposits of both collagen I and III. The above changes caused by Ang II could be inhibited fully by DMP811. CONCLUSIONS: Ang II up-regulated the expressions of collagen I, III via angiotension type 1 receptor.

Author information

Author/s: Cui, Z (Z); Chen, X (X); Chen, L (L); Wang, M (M); Liu, L (L);

Affiliation: Biochemistry Division, Fu Wai Hospital, CAMS and PUMC, Beijing 100037.

Journal and publication information

Publication Type: English Abstract; Journal Article; Research Support, Non-U.S. Gov't

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao), published in China. (Language: chi)

Reference: 1999-Dec; vol 21 (issue 6) : pp 483-7

Dates: Created 2003/02/05; Completed 2003/10/07; Revised 2006/11/15;

PMID: 12567498, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Angiotensin II - pharmacology Animals Collagen Type I - biosynthesis; genetics Collagen Type III - biosynthesis; genetics Imidazoles - pharmacology Male Myocardium - metabolism

Myocardium - metabolism RNA, Messenger - genetics Rats Rats, Sprague-Dawley Receptors, Angiotensin - antagonists & inhibitors Tetrazoles - pharmacology Ventricular Remodeling

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; Imidazoles (0) ; RNA, Messenger (0) ; Receptors, Angiotensin (0) ; Tetrazoles (0) ; Angiotensin II (11128-99-7) ; DMP 811 (139964-19-5)

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