Research article summary (published 30 Jan 2003):

[Exocytosis as the mechanism for neural communication. A view from chromaffin cells]

(La exocitosis como mecanismo de comunicación neuronal. Una visión desde la célula cromafín.)

Full Abstract

Exocytosis constitutes the main cellular mechanism for secreting neurotransmitters. It entails the fusion of a secretory vesicle with plasma membrane, thus promoting the release of its soluble content. Among the cell models that have provided insight into molecular machinery underlying the succesive steps of exocytosis, adrenal chromaffin cells have taken a prominent place. Exocytosis gave support to the classical quantal theory, which maintains that neurotransmitters are released as discrete packages from the nerve terminals towards the postsynaptic cell. We present here a brief review of the estate of our knowlegments about the secretory vesicle traffic towards the cell membrane and how exocytosis takes place through the so called SNARE hypothesis. We also review the novel mechanisms implicated in the regulation of the late steps of exocytosis as well as their possible role as target for drug therapy

Author information

Author/s: Camacho, M (M); Montesinos, M S (MS); Machado, J D (JD); Borges, R (R);

Affiliation: Unidad de Farmacología, Facultad de Medicina, Universidad de La Laguna. Tenerife, España.

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Revista de neurologia (Rev Neurol), published in Spain. (Language: spa)

Reference: -2003 Feb 15-28; vol 36 (issue 4) : pp 355-60

Dates: Created 2003/02/24; Completed 2004/02/11; Revised 2009/05/28;

PMID: 12599135, status: MEDLINE (last retrieval date: 5/28/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cell Communication - physiology Cell Membrane - metabolism Chromaffin Cells - metabolism Electrophysiology Exocytosis - physiology

Neurons - cytology; metabolism Neurotransmitter Agents - metabolism Secretory Vesicles - metabolism Synapses - metabolism Synaptic Transmission - physiology

Associated Chemicals: Neurotransmitter Agents (0)

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