Research article summary (published 23 Apr 2003):

[Two consecutive pregnancies in a type 1 diabetic under treatment with insulin Lispro]

(Zwei konsekutive komplikationslose Schwangerschaften einer Typ-1-Diabetikerin unter Insulin Lispro.)

Full Abstract

BACKGROUND: Glucose control is mandatory in pregnant women with type 1 diabetes to keep the incidence of malformations and complications low. Insulin Lispro is a new and popular fast-acting insulin analog used for intensified insulin therapy. Although popular among young patients, this drug has not been licensed for use in pregnancy due to a possibly increased risk of fetal malformations. CASE REPORT: Retrospectively, the case of a 34-year-old woman with diabetes type 1, gravid III and para III, which carried her second and third child full time under Lispro treatment, was analyzed. We performed an interview of the patient and her doctors. Additionally, the pregnancy documents along with the examination documents of the children, our patient files, and the blood glucose documentation were investigated. Contrary to the first pregnancy which was carried out in the absence of Lispro (first degree hip dysplasia), both subsequent pregnancies were completely normal despite continuous Lispro therapy. HbA(1c) values in the range of 4.9-5.9% showed an adequate glucose control throughout these pregnancies. CONCLUSION: This case supports the hypothesis that insulin Lispro which is highly popular among young patients can safely and effectively be used in pregnancies. In order to be able to adequately assess possible risks associated with this application, additional cases need to be documented and analyzed.

Author information

Author/s: Ahlbach, Sandra (S); Usadel, Klaus-Henning (KH); Badenhoop, Klaus (K);

Affiliation: Medizinische Klinik I, Endocrinology/Angiologie, Zentrum der Inneren Medizin I, Johann Wolfgang Goethe-Universität, Frankfurt am Main. Sandra.Ahlbach(-atsign-)kgu.de

Journal and publication information

Publication Type: Case Reports; English Abstract; Journal Article

Journal: Medizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)), published in Germany. (Language: ger)

Reference: 2003-Apr; vol 98 (issue 5) : pp 245-7

Dates: Created 2003/04/30; Completed 2004/01/05; Revised 2006/11/15;

PMID: 12721667, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Abnormalities, Drug-Induced - blood; etiology Blood Glucose - metabolism Diabetes Mellitus, Type 1 - blood; drug therapy Female Hemoglobin A, Glycosylated - metabolism Humans

Humans Infant, Newborn Insulin - administration & dosage; adverse effects; analogs & derivatives Pregnancy Pregnancy in Diabetics - blood; drug therapy Risk

Associated Chemicals: Blood Glucose (0) ; Hemoglobin A, Glycosylated (0) ; Insulin (11061-68-0) ; insulin LISPRO (133107-64-9)

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