Cholinergic modulation of skill learning and plasticity.

Full Abstract

The basal forebrain cholinergic system strongly influences both cortical plasticity and learning. Directly relating these two roles has proven difficult. New results indicate that nucleus basalis lesions prevent motor cortex map plasticity and impair skill learning. These results strengthen the hypothesis that nucleus basalis gates neural plasticity necessary for instrumental learning.

Author information

Author/s: Kilgard, Michael (M);

Affiliation: Department of Cognition and Neuroscience, University of Texas, Dallas, School of Human Development, Gr 41, Richardson, TX 75083, USA.

Journal and publication information

Publication Type: Comment; Journal Article; Review

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2003-Jun; vol 38 (issue 5) : pp 678-80

Dates: Created 2003/06/11; Completed 2003/07/16; Revised 2005/11/16;

PMID: 12797952, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentOn: Neuron. 2003 Jun 5;38(5):819-29. (PMID: 12797965)

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