Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder.

Full Abstract

Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder. Many of these studies have been conducted among males in specialized settings. Studies of BPD females, who constitute the majority of BPD patients, are generally conducted in community settings and report inconsistent findings. We studied gender differences in behavioral impulsivity and the prolactin response to D,L-fenfluramine (FEN) in BPD subjects in a community setting. A FEN challenge study was conducted with 64 BPD subjects (20 male, 44 female), and 57 controls (36 male, 21 female). Axis I and II disorders, including BPD, and suicidal histories were assessed by structured interviews. Controls were free of Axis I and II disorders. Impulsivity and aggression were assessed by the Buss-Durkee Hostility Inventory, Barratt Impulsiveness Scale, Minnesota Multiphasic Personality Inventory-Psychopathic Deviate subscale, and the Brown-Goodwin Lifetime History of Aggression. Male, but not female, BPD subjects had significantly diminished prolactin responses compared to controls. Impulsivity and aggression each predicted prolactin responses. A significant effect of BPD diagnosis on prolactin response was eliminated when impulsivity was co-varied. Impulsivity and aggression were inversely related to delta-prolactin and peak-prolactin responses among male but not female subjects. Gender differences in central serotonergic function may contribute to variations in impulsivity in BPD.

Author information

Author/s: Soloff, Paul H (PH); Kelly, Thomas M (TM); Strotmeyer, Stephen J (SJ); Malone, Kevin M (KM); Mann, J John (JJ);

Affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA, USA. soloffph(-atsign-)msx.upmc.edu

Grants: M01RR00056 (Agency:NCRR NIH HHS) ; MH RO1 48463 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Psychiatry research (Psychiatry Res), published in Ireland. (Language: eng)

Reference: 2003-Jul; vol 119 (issue 1-2) : pp 11-24

Dates: Created 2003/07/15; Completed 2004/08/24; Revised 2008/04/17;

PMID: 12860356, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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