Cytotoxic diterpenes from Scoparia dulcis.

Full Abstract

Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.

Author information

Author/s: Ahsan, Monira (M); Islam, S K N (SK); Gray, Alexander I (AI); Stimson, William H (WH);

Affiliation: Department of Pharmacy and Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh. monira(-atsign-)smpt.udhaka.net

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2003-Jul; vol 66 (issue 7) : pp 958-61

Dates: Created 2003/07/25; Completed 2004/02/23; Revised 2006/11/15;

PMID: 12880314, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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