Research article summary (published 30 Jul 2003):

Changes in respiratory and circulatory functions during sequential invasive-noninvasive mechanical ventilation.

Full Abstract

OBJECTIVE: To investigate the changes in respiratory and circulatory functions in chronic obstructive pulmonary disease (COPD) patients during sequential invasive-noninvasive mechanical ventilation therapy, and evaluate the effects of this new technique. METHODS: Twelve COPD patients with type II respiratory failure due to severe pulmonary infection were ventilated through an endotracheal tube. When the pulmonary infection control window (PIC-Window) occurred, the patients were extubated and were ventilated with a facial mask using pressure support ventilation combined with positive end-expiratory pressure. The parameters of hemodynamics, oxygen dynamics, and esophageal pressure were measured at the PIC-Window during invasive mechanical ventilation, one hour after oxygen therapy via a naso-tube, and three hours after non-invasive mechanical ventilation. RESULTS: The variation in esophageal pressure was 20.0 +/- 6 cmH(2)O during naso-tube oxygen therapy, and this variation was higher than that during non-invasive mechanical ventilation (10 +/- 6 cmH(2)O, P < 0.01). The changes in respiratory and circulatory parameters were not significantly different between invasive mechanical ventilation and noninvasive mechanical ventilation (P > 0.05). CONCLUSIONS: The respiratory and circulatory functions of COPD patients remained stable during sequential invasive-noninvasive mechanical ventilation therapy using PIC-Window as a switch point for early extubation. The COPD patients can tolerated the transition from invasive mechanical ventilation to noninvasive mechanical ventilation.

Author information

Author/s: Shang, Mingyu (M); Wang, Chen (C); Dai, Huaping (H); Yang, Yuanhua (Y); Jiang, Chaomei (C);

Affiliation: Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital University of Medical Science, Beijing 100020, China.

Journal and publication information

Publication Type: Journal Article

Journal: Chinese medical journal (Chin Med J (Engl)), published in China. (Language: eng)

Reference: 2003-Aug; vol 116 (issue 8) : pp 1253-6

Dates: Created 2003/08/25; Completed 2003/11/07; Revised 2008/11/21;

PMID: 12935422, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Blood Circulation - physiology Female Humans

Male Pulmonary Disease, Chronic Obstructive - physiopathology; therapy Respiration, Artificial - methods Respiratory Physiological Phenomena

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