Research article summary (published 29 Jun 2003):

Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuria.

Full Abstract

This study examined motor control in 61 early and continuously treated patients with phenylketonuria (PKU) and 69 control participants, aged 7 to 14 years. The pursuit task demanded concurrent planning and execution of unpredictable movements, whereas the tracking task required a highly automated circular movement that could be planned in advance. PKU patients showed significantly poorer motor control in both tasks compared with control participants. Deficits were particularly observed for younger patients (age < 11 years). Differences between control participants and PKU patients were significantly greater in the pursuit task compared with the tracking task, indicating more serious deficits when a higher level of controlled processing is required. Correlations with historical phenylalanine levels indicated a later maturation of the level of control required by the pursuit task compared with the tracking task.

Author information

Author/s: Huijbregts, S C J (SC); De Sonneville, L M J (LM); Van Spronsen, F J (FJ); Berends, I E (IE); Licht, R (R); Verkerk, P H (PH); Sergeant, J A (JA);

Affiliation: Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, The Netherlands. stephan.huijbregts(-atsign-)umontreal.ca

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuropsychology (Neuropsychology), published in United States. (Language: eng)

Reference: 2003-Jul; vol 17 (issue 3) : pp 369-79

Dates: Created 2003/09/08; Completed 2003/10/31; Revised 2006/11/15;

PMID: 12959503, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Age Factors Case-Control Studies Child Female Humans Male

Motor Skills Neuropsychological Tests Phenylalanine - blood Phenylketonurias - blood; psychology; therapy Psychomotor Performance Reaction Time Task Performance and Analysis

Associated Chemicals: Phenylalanine (63-91-2)

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