Research article summary (published 13 Dec 1975):

[Activity of somatostatin-containing cells of the Ilets of Langerhans in experimental diabetes]

(Réactivité de la cellule à somatostatine de l'ilot de Langerhans dans le diabète expérimental)

Full Abstract

Insulin-, glucagon-, and somatostatin-containing cells were evaluated by morphometry in sections of pancreas treated for immunofluorescence. Glucagon- and somatostatin-containing cells were found to be increased in islets of streptozotocin-diabetic rats as compared to control islets.

Author information

Author/s: Orci, L (L); Baetens, D (D); Rufener, C (C); Amherdt, M (M); Ravazzola, M (M); Studer, P (P); Malaisse-Lagae, F (F); Unger, R H (RH);

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles (C R Acad Sci Hebd Seances Acad Sci D), published in FRANCE. (Language: fre)

Reference: 1975-Dec; vol 281 (issue 23) : pp 1883-5

Dates: Created 1976/07/06; Completed 1976/07/06; Revised 2006/11/15;

PMID: 130991, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Diabetes Mellitus - metabolism; pathology Glucagon - metabolism Insulin - metabolism

Islets of Langerhans - cytology; metabolism Rats Somatostatin - metabolism Streptozocin

Associated Chemicals: Insulin (11061-68-0) ; Streptozocin (18883-66-4) ; Somatostatin (51110-01-1) ; Glucagon (9007-92-5)

Related articles

These are the highest related articles currently in the database:

• Can we make surrogate beta-cells better than the original? 30 May 2004
• Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. 29 Jun 2007
• Does IGF-I stimulate pancreatic islet cell growth? 30 Dec 2006
• Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. 29 Sep 2006
• The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis. 11 Jan 2005
• Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats. 29 Sep 2004
• Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. 7 Jul 2004
• Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. 29 Jun 2004
• Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice. 22 May 2006
• Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. 7 Nov 2006

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.