Increased somatostatin content of islets from streptozotocin-diabetic rats.

Full Abstract

Pancreatic islets were isolated from control and streptozotocin-diabetic rats. Somatostatin content as determined by radioimmunoassay was strikingly increased in the diabetic group. Immunoreactive insulin content was markedly reduced and glucagon was moderately increased. The mechanisms responsible for the somatostatin changes are unknown.

Author information

Author/s: Patel, Y C (YC); Weir, G C (GC);

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Clinical endocrinology (Clin Endocrinol (Oxf)), published in ENGLAND. (Language: eng)

Reference: 1976-Mar; vol 5 (issue 2) : pp 191-4

Dates: Created 1976/08/02; Completed 1976/08/02; Revised 2006/11/15;

PMID: 131661, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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