Agrin isoforms and their role in synaptogenesis.

Full Abstract

Agrin is thought to mediate the motor neuron-induced aggregation of synaptic proteins on the surface of muscle fibers at neuromuscular junctions. Recent experiments provide direct evidence in support of this hypothesis, reveal the nature of agrin immunoreactivity at sites other than neuromuscular junctions, and have resulted in findings that are consistent with the possibility that agrin plays a role in synaptogenesis throughout the nervous system.

Author information

Author/s: McMahan, U J (UJ); Horton, S E (SE); Werle, M J (MJ); Honig, L S (LS); Kröger, S (S); Ruegg, M A (MA); Escher, G (G);

Affiliation: Department of Neurobiology, Stanford University School of Medicine, California 94305-5401.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Current opinion in cell biology (Curr Opin Cell Biol), published in UNITED STATES. (Language: eng)

Reference: 1992-Oct; vol 4 (issue 5) : pp 869-74

Dates: Created 1992/12/21; Completed 1992/12/21; Revised 2005/11/16;

PMID: 1329871, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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