Research article summary (published 29 Sep 1992):

[The vir-regulon of Streptococcus pyogenes: coordinate expression of important virulence factors]

(Das Vir-Regulon von Streptococcus pyogenes: Koordinierte Expression wichtiger Virulenzfaktoren.)

Full Abstract

Streptococcus pyogenes (group A streptococci; GAS) expresses important virulence factors like the antiphagocytic M protein, the complement factor-inactivating C5a peptidase and the immunoglobulin-Fc-binding proteins on its surface. The corresponding emm, scpA, and emm-related (fcrA, ennX) genes are adjacently encoded on the genome. They are coordinately in trans regulated by the positive regulatory VirR factor. The responsible virR gene is also located within this segment of the genome which was called vir-regulon. There are at least three different types of organization of the vir-regulon. A frequently encountered type is the "Large vir-regulon". It comprises from 5' to 3' the following genes: virR, fcrA, a relatively small emm, ennX, and a 4.6 kb version of scpA. Another common type is the "Small vir-regulon", which contains a virR deviating in its 3'-region, a relatively large emm, and a 3.5 kb version of scpA. The "Unusual vir-regulon" is less frequently detected. It closely resembles the small one, but harbors an additional 3 to 4 kb DNA fragment between emm and scpA, occasionally encoding an emm-related gene. The type of vir-regulon encoded by a GAS strain correlates to its serotype, its M class, and its expression of serum opacity factor. The structural genes of the vir-regulon are expressed at a high level during growth in exponential phase, under anaerobiosis, and at body temperature. The sensor molecule which modulates VirR activity according to these environmental conditions has not yet been detected.(ABSTRACT TRUNCATED AT 250 WORDS)

Author information

Author/s: Podbielski, A (A); Kaufhold, A (A); Lütticken, R (R);

Affiliation: Institut für Medizinische Mikrobiologie, Rheinisch-Westfälischen Technischen Hochschule, (RWTH), Aachen.

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Immunität und Infektion (Immun Infekt), published in GERMANY. (Language: ger)

Reference: 1992-Oct; vol 20 (issue 5) : pp 161-8

Dates: Created 1993/01/07; Completed 1993/01/07; Revised 2006/11/15;

PMID: 1452195, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adhesins, Bacterial Amino Acid Sequence Bacterial Proteins - genetics DNA, Bacterial - genetics Endopeptidases - genetics Gene Expression Regulation, Bacterial

Genes, Bacterial Genes, Regulator Lymphokines - genetics Molecular Sequence Data Prostatic Secretory Proteins Streptococcus pyogenes - genetics; pathogenicity

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Adhesins, Bacterial (0) ; Bacterial Proteins (0) ; DNA, Bacterial (0) ; Lymphokines (0) ; Prostatic Secretory Proteins (0) ; beta-microseminoprotein (0) ; immunoglobulin-binding factors (0) ; Endopeptidases (EC 3.4.-) ; C5a peptidase (EC 3.4.99.-)

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