Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient.

Full Abstract

The use of psychostimulants to treat attention-deficit/hyperactivity disorder (ADHD) has been controversial for a number of reasons. In an effort to clarify the extent to which the psychostimulant methylphenidate has abuse potential, the existing published evidence has been reviewed and is summarized here, with an emphasis on delineating a number of related but independent issues that are often confused. Methylphenidate produces behavioral effects associated with abuse potential as assessed by traditional assays, but the relevance of this literature to the clinical use of the drug in the treatment of ADHD is ambiguous at best. Existing neuropharmacologic data suggest that methylphenidate has pharmacokinetic properties that reduce its abuse potential as compared with other stimulant drugs of abuse, such as cocaine.

Author information

Author/s: Kollins, Scott H (SH);

Affiliation: Duke Child and Family Study Center, Duke University Medical Center, Durham, NC 27705, USA. kolli001(-atsign-)mc.duke.edu

Journal and publication information

Publication Type: Comparative Study; Journal Article; Review

Journal: The Journal of clinical psychiatry (J Clin Psychiatry), published in United States. (Language: eng)

Reference: 2003-; vol 64 Suppl 11 (issue ) : pp 14-8

Dates: Created 2003/10/07; Completed 2004/01/12; Revised 2006/11/15;

PMID: 14529325, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

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