Research article summary (published 29 Sep 2003):

Human placental growth hormone, insulin-like growth factor I and -II, and insulin requirements during pregnancy in type 1 diabetes.

Full Abstract

Human placental GH (hPGH) replaces pituitary GH during pregnancy. hPGH is correlated to serum IGF-I in normal pregnancies and in pregnancies complicated by fetoplacental disorders. In gestational diabetes and type 2 diabetes no correlation between hPGH and IGF-I has been found. The relationship between hPGH and IGF-I in type 1 diabetes mellitus has not been investigated thoroughly. Furthermore, hPGH may be involved in the development of insulin resistance during pregnancy. In this prospective, longitudinal study, 51 type 1 diabetic subjects were followed with repeated blood sampling during pregnancy (median, 14 blood samples/subject; range, 8-26). Maternal concentrations of serum hPGH, IGF-I, and IGF-II were measured and compared with insulin requirements and birth characteristics. hPGH was detected from as early as 6 wk gestation. In all subjects, a rise in serum hPGH was observed during pregnancy, and the rise between wk 16 and 25 was correlated to the rise between wk 26 and 35 (P < 0.001). From wk 26 onward, the increase in hPGH values was significantly correlated to the birth weight, expressed as a z-score (r(s) = 0.54; P < 0.001), as were the absolute hPGH values. Also, a positive influence of hPGH on placental weight was found. Serum IGF-I values decreased significantly from the first to the second trimester (P

Author information

Author/s: Fuglsang, Jens (J); Lauszus, Finn (F); Flyvbjerg, Allan (A); Ovesen, Per (P);

Affiliation: Gynecological/Obstetrical Research Department Y, Aarhus University Hospital, Skejby Sygehus, DK-8200 Aarhus N, Denmark. jens_fuglsang(-atsign-)hotmail.com

Journal and publication information

Publication Type: Corrected and Republished Article; Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab), published in United States. (Language: eng)

Reference: 2003-Oct; vol 88 (issue 10) : pp 4355-61

Dates: Created 2003/10/14; Completed 2003/11/12; Revised 2006/11/15;

PMID: 14557493, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

RepublishedFrom: J Clin Endocrinol Metab. 2003 Sep;88(9):4355-61. (PMID: 12970310)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Birth Weight Diabetes Mellitus, Type 1 - drug therapy; metabolism Female Gestational Age Growth Hormone - blood Hemoglobin A, Glycosylated - metabolism Humans Hypoglycemic Agents - blood; therapeutic use

Infant, Newborn Insulin - blood; therapeutic use Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - metabolism Organ Size Placenta - anatomy & histology Placental Hormones - blood Pregnancy Pregnancy in Diabetics - drug therapy; metabolism

Associated Chemicals: Hemoglobin A, Glycosylated (0) ; Hypoglycemic Agents (0) ; Placental Hormones (0) ; HGH-V protein, human (109675-94-7) ; Insulin (11061-68-0) ; Insulin-Like Growth Factor I (67763-96-6) ; Insulin-Like Growth Factor II (67763-97-7) ; Growth Hormone (9002-72-6)

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