Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma.

Full Abstract

Magnetic resonance imaging relaxation times, T(1rho) and Carr-Purcell T(2) (CP-T(2)), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T(1rho) and CP-T(2) measured with short spacing (tau(CP)) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T(2) measured with long tau(CP) (long-tau(CP) T(2): 54.3 +/- 0.7 and 55.4 +/- 1.2 ms, P = 0.30; short-tau(CP) T(2): 61.3 +/- 1.0 and 64.2 +/- 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-tau(CP) T(2) provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T(2) contrast can be modulated and extended in a manner likely to be clinically important.

Author information

Author/s: Gröhn, Olli H J (OH); Valonen, Piia K (PK); Lehtimäki, Kimmo K (KK); Väisänen, Tuula H (TH); Kettunen, Mikko I (MI); Ylä-Herttuala, Seppo (S); Kauppinen, Risto A (RA); Garwood, Michael (M);

Affiliation: Department of Biomedical NMR and National Bio NMR Facility, A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland. grohn(-atsign-)messi.uku.fi

Grants: CA 92004 (Agency:NCI NIH HHS) ; RR 08079 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Cancer research (Cancer Res), published in United States. (Language: eng)

Reference: 2003-Nov; vol 63 (issue 22) : pp 7571-4

Dates: Created 2003/11/24; Completed 2004/02/09; Revised 2007/11/14;

PMID: 14633668, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.