Research article summary (published Dec 2003):

Physiology of cells in the central lobes of the mormyrid cerebellum.

Full Abstract

The cerebellum of mormyrid electric fish is unusual for its size and for the regularity of its histology. The circuitry of the mormyrid cerebellum is also different from that of the mammalian cerebellum in that mormyrid Purkinje cell axons terminate locally within the cortex on efferent cells, and the cellular regions of termination for climbing fibers and parallel fibers are well separated. These and other features suggest that the mormyrid cerebellum may be a useful site for addressing some functional issues regarding cerebellar circuitry. We have therefore begun to examine the physiology of the mormyrid cerebellum by recording intracellularly from morphologically identified Purkinje cells, efferent cells, Golgi cells, and stellate cells in in vitro slices. Mormyrid Purkinje cells respond to parallel fiber input with an AMPA-mediated EPSP that shows paired pulse facilitation and to climbing fiber input with a large all-or-none AMPA-mediated EPSP that shows paired pulse depression. Recordings from the somas of Purkinje cells show three types of spikes in response to injected current: a small, narrow sodium spike; a large, broad sodium spike; and a large broad calcium spike. Efferent cells, Golgi cells, and stellate cells respond to parallel fiber input with an EPSP or EPSP-IPSP sequence and show only large, narrow spikes in response to intracellular current injection. We conclude that the physiology of the mormyrid cerebellum is similar in many ways to the mammalian cerebellum but is also different in ways that may prove instructive concerning the functional circuitry of the cerebellum.

Author information

Author/s: Han, Victor Z (VZ); Bell, Curtis C (CC);

Affiliation: Neurological Sciences Institute, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA. hanv(-atsign-)ohsu.edu

Grants: MH49792 (Agency:NIMH NIH HHS) ; NS44961 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2003-Dec; vol 23 (issue 35) : pp 11147-57

Dates: Created 2003/12/05; Completed 2003/12/23; Revised 2007/11/14;

PMID: 14657174, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - drug effects; physiology Animals Calcium Channel Blockers - pharmacology Cerebellum - cytology; drug effects; physiology Electric Fish - physiology Electric Stimulation

Excitatory Postsynaptic Potentials - physiology Lysine - analogs & derivatives Patch-Clamp Techniques Purkinje Cells - cytology; drug effects; physiology Sodium Channel Blockers - pharmacology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

Associated Chemicals: Calcium Channel Blockers (0) ; Sodium Channel Blockers (0) ; Lysine (56-87-1) ; biocytin (576-19-2) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0)

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