Cdk5: a new player at synapses.

Full Abstract

Cdk5 is a member of the cyclin-dependent kinase family. Unlike other conventional Cdks that are major regulators of eukaryotic cell cycle progression, Cdk5 displays diverse functions in neuronal as well as non-neuronal tissues. In particular, accumulating evidence points to the roles of this kinase in CNS development and other cellular processes. In this article, we summarize the functional roles of Cdk5 pertaining to the formation and functions of synapse, a specialized structure for the fundamental functions of neurons. Copyright 2003 S. Karger AG, Basel

Author information

Author/s: Cheng, Kai (K); Ip, Nancy Y (NY);

Affiliation: Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong/SAR, PR China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Neuro-Signals (Neurosignals), published in Switzerland. (Language: eng)

Reference: -2003 Sep-Oct; vol 12 (issue 4-5) : pp 180-90

Dates: Created 2003/12/15; Completed 2004/03/08; Revised 2006/11/15;

PMID: 14673204, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Nerve Tissue Proteins - metabolism
Neuromuscular Junction - enzymology; physiology
Neurotransmitter Agents - metabolism
Receptors, Neurotransmitter - metabolism
Signal Transduction - physiology
Synapses - enzymology; physiology

Associated Chemicals: Nerve Tissue Proteins (0) ; Neurotransmitter Agents (0) ; Receptors, Neurotransmitter (0) ; neuronal Cdk5 activator (p25-p35) (0) ; Cyclin-Dependent Kinase 5 (EC 2.7.1.37) ; Cyclin-Dependent Kinases (EC 2.7.1.37)

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