Research article summary (published 30 Dec 2003):

Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats.

Full Abstract

The antidiabetic activity of aqueous, ethanolic and hexanic extracts of Bauhinia forficata was investigated in a model of alloxan-induced diabetes in rats. The biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). Extracts were administered daily for 7 d at doses of 200 and 400 mg/kg, p.o., 48 h after alloxan injection (60 mg/kg, i.v.). The alloxan-diabetic rats showed significant reductions in plasma glucose, triglycerides, total cholesterol and HDL-cholesterol after treatment with the extracts and glibenclamide (used as standard) as compared to the diabetic controls. Levels of LDL were not altered. In conclusion, our results showed that the plant extracts when administered by gavage may reduce glucose, triglycerides, total cholesterol and HDL-cholesterol levels. These results suggest the validity of the clinical use of B. forficata in the treatment of diabetes mellitus type II.

Author information

Author/s: Lino, Cleide de Sousa (Cde S); Diógenes, João Paulo Luz (JP); Pereira, Bruno Azevedo (BA); Faria, Rozilaine Aparecida Pelegrine Gomes (RA); Andrade Neto, Manoel (M); Alves, Renata Sousa (RS); de Queiroz, Maria Goreti Rodrigues (MG); de Sousa, Francisca Cléa Florenço (FC); Viana, Glauce Socorro Barros (GS);

Affiliation: Department of Physiology and Pharmacology, Federal University of Ceará, Coronel Nunes de Melo 1127, 60430-270 Fortaleza, Ceará, Brazil. cleidelino(-atsign-)yahoo.com.br

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull), published in Japan. (Language: eng)

Reference: 2004-Jan; vol 27 (issue 1) : pp 125-7

Dates: Created 2004/01/07; Completed 2004/08/10; Revised 2006/11/15;

PMID: 14709915, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Bauhinia - chemistry Blood Glucose - metabolism Cholesterol - blood Cholesterol, HDL - blood Diabetes Mellitus, Experimental - blood; drug therapy Ethanol Glyburide - pharmacology Hexanes Hypoglycemic Agents - pharmacology

Lipids - blood Male Phytotherapy Plant Extracts - therapeutic use Plant Leaves - chemistry Rats Rats, Wistar Solvents Triglycerides - blood Water

Associated Chemicals: Blood Glucose (0) ; Cholesterol, HDL (0) ; Hexanes (0) ; Hypoglycemic Agents (0) ; Lipids (0) ; Plant Extracts (0) ; Solvents (0) ; Triglycerides (0) ; Glyburide (10238-21-8) ; Cholesterol (57-88-5) ; Ethanol (64-17-5) ; Water (7732-18-5)

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