Recent insights into human coronary collateral development.

Full Abstract

Enhancement of coronary collateral function is an intriguing approach to the preservation of ischaemic myocardium. Coronary collateral development consists of collateral recruitment and collateral growth. Collateral growth encompasses proliferation of capillaries in the ischaemic area (angiogenesis) and maturation of pre-existing collateral vessels (arteriogenesis), with the latter being more relevant in humans. Therefore, treatment intended directly for arteriogenesis of collateral vessels appears to be more effective. Promotion of coronary collateral growth has many attractive features, particularly in patients with angina who are not indicated for percutaneous coronary intervention or coronary artery bypass grafting surgery. A complete elucidation of the remaining practical and mechanistic questions of arteriogenesis may lead to a new remedy capable of developing collateral vessels more effectively.

Author information

Author/s: Fujita, M (M); Tambara, K (K);

Affiliation: College of Medical Technology, Kyoto University, Kyoto, Japan. mfujita(-atsign-)kuhp.kyoto-u.ac.jp

Journal and publication information

Publication Type: Journal Article; Review

Journal: Heart (British Cardiac Society) (Heart), published in England. (Language: eng)

Reference: 2004-Mar; vol 90 (issue 3) : pp 246-50

Dates: Created 2004/02/17; Completed 2004/03/16; Revised 2008/11/20;

PMID: 14966033, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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