Estimating predictors for long- or short-term survivors.

Full Abstract

Suppose that the response variable in a well-executed clinical or observational study to evaluate a treatment is the time to a certain event, and a set of baseline covariates or predictors was collected for each study patient. Furthermore, suppose that a significant number of study patients had nontrivial, long-term adverse effects from the treatment. A commonly posed question is how to use these covariates from the study to identify future patients who would (or would not) benefit from the treatment. In this article, we present "point" and "interval" estimates for the set of covariate or predictor vectors associated with a specific patient survival status, e.g., long- (or short-) term survival, in the presence of censoring. These estimates can be easily displayed on a two-dimensional plane, even for the case with high-dimensional covariate vectors. These simple numerical and graphical procedures provide useful information for patient management and/or the design of future studies, which are key issues in pharmacogenomics with genetic markers. The new proposal is illustrated with a data set from a cancer study for treating multiple myeloma.

Author information

Author/s: Tian, L (L); Wang, W (W); Wei, L J (LJ);

Affiliation: Department of Biostatistics, Harvard School of Public Health, 677 Huntington Ave., Boston, Massachusetts 02115, USA. ltian(-atsign-)hsph.harvard.edu

Grants: AI24643 (Agency:NIAID NIH HHS) ; AI52817 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Biometrics (Biometrics), published in United States. (Language: eng)

Reference: 2003-Dec; vol 59 (issue 4) : pp 1008-15

Dates: Created 2004/02/18; Completed 2004/06/29; Revised 2007/11/14;

PMID: 14969480, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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