Research article summary (published 30 Jul 2004):

Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex.

Full Abstract

Like primary reinforcers, the anticipation of reward ought to affect neurochemical release in brain regions, such as the medial prefrontal cortex (mPFC), which are associated with appraisal processes. To assess the neurochemical changes associated with anticipation, rats were exposed to the pairing of auditory (60-dB white noise), visual, and olfactory cues with the daily presentation of a palatable snack (Cue Relevant group). Rats of a second group were similarly trained, but for a 2-week period, the snack was no longer provided following cue presentation (Extinction group). In the third condition, the presentation of the snack and cues was uncorrelated (Cue Irrelevant group). Analyses of dialysates collected in vivo from the mPFC revealed that release of corticotropin-releasing hormone (CRH), gastrin-releasing peptide (GRP), and the 5-HT catabolite, 5-hydroxyindole acetic acid (5-HIAA), had increased bilaterally in response to the anticipatory cues, whereas DA release increased only within the right mPFC. In the case of CRH and GRP, these increases were also apparent in the extinction condition, despite the fact that behavioral arousal to the anticipatory cues (increased exploration, rearing, grooming, and vigilance) was only evident in the Cue Relevant condition. In contrast, the elevated DA and 5-HIAA were apparent exclusively in the Cue Relevant condition. Thus, CRH and GRP systems may serve to allocate salience and/or incentive reward value to biologically significant stimuli or reflect the emotional response to the anticipatory stimulus. The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli.

Author information

Author/s: Merali, Zul (Z); McIntosh, Judy (J); Anisman, Hymie (H);

Affiliation: School of Psychology, University of Ottawa, Ottawa, Ontario, Canada. merali(-atsign-)uottawa.ca

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology), published in United States. (Language: eng)

Reference: 2004-Aug; vol 29 (issue 8) : pp 1409-18

Dates: Created 2004/07/21; Completed 2004/09/08; Revised 2006/11/15;

PMID: 15039770, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Behavior, Animal - physiology Biogenic Monoamines - metabolism Chromatography, High Pressure Liquid Corticotropin-Releasing Hormone - metabolism Cues Dopamine - metabolism Extinction, Psychological - physiology Feeding Behavior - physiology Food Functional Laterality - physiology

Gastrin-Releasing Peptide - metabolism Hydroxyindoleacetic Acid - metabolism Male Microdialysis Motivation Neuropeptides - metabolism Prefrontal Cortex - metabolism; physiology Radioimmunoassay Rats Rats, Long-Evans Serotonin - metabolism

Associated Chemicals: Biogenic Monoamines (0) ; Neuropeptides (0) ; Serotonin (50-67-9) ; Dopamine (51-61-6) ; Hydroxyindoleacetic Acid (54-16-0) ; Gastrin-Releasing Peptide (80043-53-4) ; Corticotropin-Releasing Hormone (9015-71-8)

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